BCAA supplements are worth taking for muscle growth

Branched-chain amino acids (BCAAs — leucine, isoleucine, and valine) are widely marketed as supplements that promote muscle protein synthesis and enhance muscle growth. The claim is that supplementing with BCAAs provides meaningful benefits for hypertrophy beyond what is achieved through adequate total protein intake.

bcaabranched-chain amino acidsmuscle growthsupplementsleucine
3 studies weighed Updated

Evidence Breakdown

1 PRO
2 AGAINST

Based on 3 studies

Evidence map

For & against, at a glance

Pro Con Neutral
42.9% confidence
Claim
1 2 0
Systematic Review Pro
Fouré A & Bendahan D · 2017
Nutrients

Systematic review of 11 studies examining BCAA supplementation and exercise-induced muscle damage. The authors found moderate evidence that BCAA supplementation may reduce muscle damage markers and accelerate recovery, particularly when consumed before exercise. However, the effects on actual hypertrophy were less clear.

0.63

Systematic review of 11 studies examining BCAA supplementation and exercise-induced muscle damage. The authors found moderate evidence that BCAA supplementation may reduce muscle damage markers and accelerate recovery, particularly when consumed before exercise. However, the effects on actual hypertrophy were less clear.

Design Systematic Review (0.9) × quality 0.70 = impact 0.63

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RCT Con
Jackman SR et al. · 2017
Frontiers in Physiology

RCT comparing BCAA supplementation to whey protein and placebo after resistance exercise. While BCAAs stimulated muscle protein synthesis 22% more than placebo, whey protein stimulated synthesis 50% more than BCAAs. The authors concluded that BCAAs alone are an insufficient stimulus for maximal muscle protein synthesis.

0.60

RCT comparing BCAA supplementation to whey protein and placebo after resistance exercise. While BCAAs stimulated muscle protein synthesis 22% more than placebo, whey protein stimulated synthesis 50% more than BCAAs. The authors concluded that BCAAs alone are an insufficient stimulus for maximal muscle protein synthesis.

Design RCT (0.8) × quality 0.75 = impact 0.60

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Narrative Review Con
Wolfe RR · 2017
Journal of the International Society of Sports Nutrition

This review concluded that BCAAs alone cannot promote muscle protein synthesis to a greater extent than the rate at which other essential amino acids become available. The claim that BCAAs stimulate muscle protein synthesis independently of other amino acids was not supported. The author argued that a complete protein source is necessary for a meaningful anabolic response.

0.24

This review concluded that BCAAs alone cannot promote muscle protein synthesis to a greater extent than the rate at which other essential amino acids become available. The claim that BCAAs stimulate muscle protein synthesis independently of other amino acids was not supported. The author argued that a complete protein source is necessary for a meaningful anabolic response.

Design Narrative Review (0.3) × quality 0.80 = impact 0.24

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Evidence

PRO (1)

PRO Systematic Review 0.70 Fouré A, Bendahan D (2017)

Systematic review of 11 studies examining BCAA supplementation and exercise-induced muscle damage. The authors found moderate evidence that BCAA supplementation may reduce muscle damage markers and accelerate recovery, particularly when consumed before exercise. However, the effects on actual hypertrophy were less clear.

Nutrients

DOI: 10.3390/nu9101047

AGAINST (2)

AGAINST Narrative Review 0.80 Wolfe RR (2017)

This review concluded that BCAAs alone cannot promote muscle protein synthesis to a greater extent than the rate at which other essential amino acids become available. The claim that BCAAs stimulate muscle protein synthesis independently of other amino acids was not supported. The author argued that a complete protein source is necessary for a meaningful anabolic response.

Journal of the International Society of Sports Nutrition

DOI: 10.1186/s12970-017-0184-9

AGAINST RCT 0.75 Jackman SR, Witard OC et al. (2017)

RCT comparing BCAA supplementation to whey protein and placebo after resistance exercise. While BCAAs stimulated muscle protein synthesis 22% more than placebo, whey protein stimulated synthesis 50% more than BCAAs. The authors concluded that BCAAs alone are an insufficient stimulus for maximal muscle protein synthesis.

Frontiers in Physiology

DOI: 10.3389/fphys.2017.00390